![]() TransmiR v2.0 provides functions to "Search" by full/partial names (i.e exact and fuzzy modes, respectively) of transcription factors and microRNAs. To search data in the database by a miRNA or TF name, please click the "Search" tab in the menu (1 in Figure 1). Users can also download the datasets for further analysis. TransmiR v2.0 is freely available for academic usage. Finally, a " Predict" module was implemented, which enables the prediction of TF-miRNA regulations based on binding motif matrices of human TFs. Furthermore, we constructed " Enrichment analysis" module to identify the significant TFs that are likely to regulate a miRNA list of interest. If the user have single miRNA, TF or disease at hand,all above transcriptional regulation data can be searched and graphically visualized in " Search" page and " Network" page, respectively. All TF-miRNA regulations were annotated in detail, and experimentally validated miRNA-TF feedback regulations from miRNA target database TarBase and miRTarBase were also included. Besides, we also provide 1,785,998 TF-miRNA regulations derived from ChIP-seq evidence in 5 species. Currently, TransmiR v2.0 contains 3,730 literature-curated TF-miRNA regulations, which cover ~623 TFs, ~785 miRNAs, 19 organisms and 1,349 publications. In this major update to TransmiR v2.0, we manually curated 2,852 TF-miRNA regulations from 1,045 publications during 2013-2017 and included ChIP-seq-derived TF-miRNA regulation data. TransmiR was originally constructed on September 2009 and updated on January 2013. TransmiR is a database for transcription factor (TF)-microRNA (miRNA) regulations, through which one can find regulatory relations between TFs and miRNAs. But the underlying mechanisms remain elusive, partly because the integrative data of transcription factor (TF)-miRNA regulations is far from sufficient. It has been reported that aberrant regulation of miRNAs was associated with the development and progression of various diseases, including cancer, cardiovascular disease, etc. MicroRNAs(miRNAs) are important post-transcriptional regulators of gene expression and play critical roles in various biological processes. Which genome assemblies were used in TransmiR v2.0?.What is the difference between the evidence level 1 and level 2?.What does microRNA annotation information include?.What does transcription factor annotation information include?.How to use " Enrichment analysis" function?.This website has been tested by using Chrome, Microsoft Edge and Firefox browsers. If the user have single miRNA, TF or disease at hand, all above transcriptional regulation data can be searched and graphically visualized in " Search" page and " Network" page, respectively.
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